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Deficient SUMO Attachment to Flp Recombinase Leads to Homologous Recombination-dependent Hyperamplification of the Yeast 2 μm Circle Plasmid

Many Saccharomyces cerevisiae mutants defective in the SUMO pathway accumulate elevated levels of the native 2 μm circle plasmid (2 μm). Here we show that accumulation of 2 μm in the SUMO pathway mutants siz1Δ siz2Δ, slx5Δ, and slx8Δ is associated with formation of an aberrant high-molecular-weight...

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Autors principals: Xiong, Ling, Chen, Xiaole L., Silver, Hannah R., Ahmed, Noreen T., Johnson, Erica S.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642740/
https://ncbi.nlm.nih.gov/pubmed/19109426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-06-0659
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