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A New Method for Ligand Docking to Flexible Receptors by Dual Alanine Scanning and Refinement (SCARE)

Protein binding sites undergo ligand specific conformational changes upon ligand binding. However, most docking protocols rely on a fixed conformation of the receptor, or on the prior knowledge of multiple conformations representing the variation of the pocket, or on a known bounding box for the lig...

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Bibliografiske detaljer
Main Authors: Bottegoni, Giovanni, Kufareva, Irina, Totrov, Maxim, Abagyan, Ruben
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2641994/
https://ncbi.nlm.nih.gov/pubmed/18273556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-008-9188-5
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