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Distinct Mechanisms of Regulation by Ca(2+)/Calmodulin of Type 1 and 8 Adenylyl Cyclases Support Their Different Physiological Roles

Nine membrane-bound mammalian adenylyl cyclases (ACs) have been identified. Type 1 and 8 ACs (AC1 and AC8), which are both expressed in the brain and are stimulated by Ca(2+)/calmodulin (CaM), have discrete neuronal functions. Although the Ca(2+) sensitivity of AC1 is higher than that of AC8, precis...

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Detalhes bibliográficos
Main Authors: Masada, Nanako, Ciruela, Antonio, MacDougall, David A., Cooper, Dermot M. F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640985/
https://ncbi.nlm.nih.gov/pubmed/19029295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807359200
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