The neurotrophin receptor p75(NTR) triggers endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impairment of reparative neovascularization

Diabetes compromises endothelial function and inhibits reparative neovascularization. The neurotrophin receptor p75(NTR) is scarcely present in healthy endothelial cells (EC), but diabetes induces p75(NTR) in capillary EC of ischemic limb muscles. Here, we show that forced p75(NTR) expression impair...

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Main Authors: Caporali, Andrea, Pani, Elisabetta, Horrevoets, Anton J. G., Kraenkel, Nicolle, Oikawa, Atsuhiko, Sala-Newby, Graciela B., Meloni, Marco, Cristofaro, Brunella, Graiani, Gallia, Leroyer, Aurelie, Boulanger, Chantal, Herman, Andrew, Spinetti, Gaia, Yoon, Sung Ok, Madeddu, Paolo, Emanueli, Costanza
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640941/
https://ncbi.nlm.nih.gov/pubmed/18566344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.177386
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