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Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones

T cells recognize antigen by formation of a trimolecular complex in which the T-cell receptor (TCR) recognizes a specific peptide antigen within the groove of a major histocompatibility complex (MHC) molecule. It has generally been assumed that T-cell recognition of two distinct MHC–antigen complexe...

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Main Authors: Ausubel, Lara J., Kwan, Candice K., Sette, Alessandro, Kuchroo, Vijay, Hafler, David A.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences of the USA 1996
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC26402/
https://ncbi.nlm.nih.gov/pubmed/8986809
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