The Structure of Phosphorylase Kinase Holoenzyme at 9.9 Å Resolution and Location of the Catalytic Subunit and the Substrate Glycogen Phosphorylase

Phosphorylase kinase (PhK) coordinates hormonal and neuronal signals to initiate the breakdown of glycogen. The enzyme catalyzes the phosphorylation of inactive glycogen phosphorylase b (GPb), resulting in the formation of active glycogen phosphorylase a. We present a 9.9 Å resolution structure of P...

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Hauptverfasser: Vénien-Bryan, Catherine, Jonic, Slavica, Skamnaki, Vasiliki, Brown, Nick, Bischler, Nicolas, Oikonomakos, Nikos G., Boisset, Nicolas, Johnson, Louise N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639635/
https://ncbi.nlm.nih.gov/pubmed/19141288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.10.013
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