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FR258900, a potential anti-hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase
FR258900 has been discovered as a novel inhibitor of human liver glycogen phosphorylase a and proved to suppress hepatic glycogen breakdown and reduce plasma glucose concentrations in diabetic mice models. To elucidate the mechanism of inhibition, we have determined the crystal structure of the cocr...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2203354/ https://ncbi.nlm.nih.gov/pubmed/17600143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.072925607 |
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