Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21(Cip/WAF1 )pathway

BACKGROUND: Valproic acid (VPA), a commonly used mood stabilizer that promotes neuronal differentiation, regulates multiple signaling pathways involving extracellular signal-regulated kinase (ERK) and glycogen synthase kinase3β (GSK3β). However, the mechanism by which VPA promotes differentiation is...

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Main Authors: Jung, Gyung-Ah, Yoon, Ju-Yong, Moon, Byoung-San, Yang, Dong-Hwa, Kim, Hyun-Yi, Lee, Sang-Hun, Bryja, Vitezslav, Arenas, Ernest, Choi, Kang-Yell
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639384/
https://ncbi.nlm.nih.gov/pubmed/19068119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-9-66
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