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Effect of calcium-sensing receptor activation in models of autosomal recessive or dominant polycystic kidney disease

Background. Antagonists of relevant Gs protein-coupled and agonists of relevant Gi protein-coupled receptors lower renal cAMP and inhibit growth of renal cysts in animal models of human ARPKD (PCK rat) and/or ADPKD (Pkd2(−/WS25) mouse). A calcium-sensing receptor (CaR) is expressed in various tubula...

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Hlavní autoři: Wang, Xiaofang, Harris, Peter C., Somlo, Stefan, Batlle, Daniel, Torres, Vicente E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639335/
https://ncbi.nlm.nih.gov/pubmed/18826972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfn527
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