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Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle

OBJECTIVES: We sought to improve upon the usefulness of artemisinins as anti-Toxoplasma agents by synthesizing new unsaturated, carba derivatives and then testing them for in vitro efficacy against three steps of the lytic cycle of Toxoplasma gondii tachyzoites. METHODS: Novel derivatives of ART wer...

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Main Authors: D'Angelo, John G., Bordón, Claudia, Posner, Gary H., Yolken, Robert, Jones-Brando, Lorraine
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639242/
https://ncbi.nlm.nih.gov/pubmed/18988681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkn451
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