Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2

Bone morphogenetic proteins (BMPs) have an emerging role in human cancers. Here we demonstrate that the BMP-signaling pathway is intact and functional in human pancreatic cancer cells, with several BMP signaling components and transcriptional targets upregulated in human pancreatic cancer specimens...

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Main Authors: Gordon, Kelly J., Kirkbride, Kellye C., How, Tam, Blobe, Gerard C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2009
Ábhair:
Cancer Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639045/
https://ncbi.nlm.nih.gov/pubmed/19056927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn274
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