Isorhodopsin rather than rhodopsin mediates rod function in RPE65 knock-out mice
The chromophore of visual pigments is 11-cis-retinal and, thus, in its absence, opsin is not photosensitive and no visual function exists. However, in the RPE65 knockout (Rpe65(-/-)) mouse, where synthesis of 11-cis-retinal does not occur, a minimal visual response from rod photoreceptors is obtaine...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC263870/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14578454/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2234461100 |
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