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Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation

Human cells are known to be more refractory than rodent cells against oncogenic transformation in vitro. To date, the molecular mechanisms underlying such resistance remain largely unknown. The combination of simian virus 40 early region and H-Ras V12 has been effective for transformation of rat emb...

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Detalles Bibliográficos
Main Authors: Akagi, Tsuyoshi, Sasai, Ken, Hanafusa, Hidesaburo
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC263854/
https://ncbi.nlm.nih.gov/pubmed/14597713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1834876100
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