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Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation

Human cells are known to be more refractory than rodent cells against oncogenic transformation in vitro. To date, the molecular mechanisms underlying such resistance remain largely unknown. The combination of simian virus 40 early region and H-Ras V12 has been effective for transformation of rat emb...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Akagi, Tsuyoshi, Sasai, Ken, Hanafusa, Hidesaburo
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC263854/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14597713/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1834876100
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