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Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages

In rheumatoid arthritis, peripheral blood T cells have age-inappropriate telomeric erosion. We examined whether HLA-DRB1*04 alleles, the major susceptibility genes for this disease, confer risk for T cell senescence. In healthy individuals, HLA-DRB1*04 alleles were associated with excessive loss of...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Schönland, Stefan O., Lopez, Consuelo, Widmann, Thomas, Zimmer, Julia, Bryl, Ewa, Goronzy, Jörg J., Weyand, Cornelia M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC263838/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14578453/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2233561100
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