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Synthesis of Pluraflavin A “Aglycone”

The “aglycone” of pluraflavin A (2) has been synthesized. The key features of this synthesis include a 1,3-dipolar cycloaddition between a nitrile oxide (cf. 14) and an olefin (22) to yield an isoxazoline followed by subsequent conversion into the γ-pyrone of pluraflavin A. The epoxide moiety linked...

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Detalles Bibliográficos
Main Authors: Wright, Benjamin J.D., Hartung, John, Peng, Feng, Van de Water, Ryan, Liu, Haibo, Tan, Quen-Hui, Chou, Ting-Chao, Danishefsky, Samuel J.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638005/
https://ncbi.nlm.nih.gov/pubmed/19049469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja805936v
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