Detecting coevolution without phylogenetic trees? Tree-ignorant metrics of coevolution perform as well as tree-aware metrics

BACKGROUND: Identifying coevolving positions in protein sequences has myriad applications, ranging from understanding and predicting the structure of single molecules to generating proteome-wide predictions of interactions. Algorithms for detecting coevolving positions can be classified into two cat...

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Bibliographic Details
Main Authors: Caporaso, J Gregory, Smit, Sandra, Easton, Brett C, Hunter, Lawrence, Huttley, Gavin A, Knight, Rob
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Methodology Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637866/
https://ncbi.nlm.nih.gov/pubmed/19055758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-8-327
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