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Controlled surface modification with poly(ethylene)glycol enhances diffusion of PLGA nanoparticles in human cervical mucus

Drug delivery to mucosal epithelia is severely limited by the mucus gel, which is a physical diffusion barrier as well as an enzymatic barrier in some sites. Loading of drug into polymer particles can protect drugs from degradation and enhance their stability. To improve efficacy of nanoparticulate...

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Detalhes bibliográficos
Main Authors: Cu, Yen, Saltzman, W. Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637413/
https://ncbi.nlm.nih.gov/pubmed/19053536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp8001254
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