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Intracellular Zn(2+) Accumulation Contributes to Synaptic Failure, Mitochondrial Depolarization, and Cell Death in an Acute Slice Oxygen–Glucose Deprivation Model of Ischemia

Despite considerable evidence for contributions of both Zn(2+) and Ca(2+) in ischemic brain damage, the relative importance of each cation to very early events in injury cascades is not well known. We examined Ca(2+) and Zn(2+) dynamics in hippocampal slices subjected to oxygen–glucose deprivation (...

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Detalhes bibliográficos
Main Authors: Medvedeva, Yuliya V., Lin, Bin, Shuttleworth, C. William, Weiss, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637403/
https://ncbi.nlm.nih.gov/pubmed/19176819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4604-08.2009
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