Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan

Large, long-lived species experience more lifetime cell divisions and hence a greater risk of spontaneous tumor formation than smaller, short-lived species. Large, long-lived species are thus expected to evolve more elaborate tumor suppressor systems. In previous work, we showed that telomerase acti...

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Autori principali: Seluanov, Andrei, Hine, Christopher, Bozzella, Michael, Hall, Amelia, Sasahara, Tais H. C., Ribeiro, Antonio A. C. M., Catania, Kenneth C., Presgraves, Daven C., Gorbunova, Vera
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637185/
https://ncbi.nlm.nih.gov/pubmed/18778411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2008.00431.x
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