Plasmin in Nephrotic Urine Activates the Epithelial Sodium Channel

Proteinuria and increased renal reabsorption of NaCl characterize the nephrotic syndrome. Here, we show that protein-rich urine from nephrotic rats and from patients with nephrotic syndrome activate the epithelial sodium channel (ENaC) in cultured M-1 mouse collecting duct cells and in Xenopus laevi...

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Main Authors: Svenningsen, Per, Bistrup, Claus, Friis, Ulla G., Bertog, Marko, Haerteis, Silke, Krueger, Bettina, Stubbe, Jane, Jensen, Ole Nørregaard, Thiesson, Helle C., Uhrenholt, Torben R., Jespersen, Bente, Jensen, Boye L., Korbmacher, Christoph, Skøtt, Ole
格式: Artigo
語言:Inglês
出版: American Society of Nephrology 2009
主題:
Basic Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637049/
https://ncbi.nlm.nih.gov/pubmed/19073825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008040364
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