Restoration of the antiviral activity of 3′-azido-3′-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cells

Emergence of antiviral drug resistance is a major challenge to human immunodeficiency virus (HIV) therapy. The archetypal example of this problem is loss of antiviral activity of the nucleoside analogue 3′-azido-3′-deoxythymidine (AZT), caused by mutations in reverse transcriptase (RT), the viral po...

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Bibliographic Details
Main Authors: Lavie, Arnon, Su, Ying, Ghassemi, Mahmood, Novak, Richard M., Caffrey, Michael, Sekulic, Nikolina, Monnerjahn, Christian, Konrad, Manfred, Cook, James L.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636676/
https://ncbi.nlm.nih.gov/pubmed/18559937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.2008/000273-0
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