Effect of Locked-Nucleic Acid on a Biologically Active G-Quadruplex. A Structure-Activity Relationship of the Thrombin Aptamer

Here we tested the ability to augment the biological activity of the thrombin aptamer, d(GGTTGGTGTGGTTGG), by using locked nucleic acid (LNA) to influence its G-quadruplex structure. Compared to un-substituted control aptamer, LNA-containing aptamers displayed varying degrees of thrombin inhibition....

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Bibliographic Details
Main Authors: Bonifacio, Laura, Church, Frank C., Jarstfer, Michael B.
Format: Artigo
Language:Inglês
Published: Molecular Diversity Preservation International (MDPI) 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635671/
https://ncbi.nlm.nih.gov/pubmed/19325759
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