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Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

The β cell-specific glucose-sensitive factor (GSF), which binds the A3 motif of the rat I and human insulin promoters, is modulated by extracellular glucose. A single mutation in the GSF binding site of the human insulin promoter abolishes the stimulation by high glucose only in normal islets, suppo...

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Autors principals: Marshak, Sonya, Totary, Hana, Cerasi, Erol, Melloul, Danielle
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1996
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC26355/
https://ncbi.nlm.nih.gov/pubmed/8986763
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