Rapid platelet turnover in WASP(−) mice correlates with increased ex vivo phagocytosis of opsonized WASP(−) platelets

OBJECTIVE: Our objective was to determine a mechanism for the thrombocytopenia of murine Wiskott-Aldrich syndrome (WAS). MATERIALS AND METHODS: Consumption rates of WAS protein (WASP)( −) and wild-type (WT) platelets were measured by injection of 5-chloromethylfluorescein diacetate (CMFDA)-labeled p...

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Autores principales: Prislovsky, Amanda, Marathe, Bindumadhav, Hosni, Amira, Bolen, Alyssa L., Nimmerjahn, Falk, Jackson, Carl W., Weiman, Darryl, Strom, Ted S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635498/
https://ncbi.nlm.nih.gov/pubmed/18346836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2007.12.019
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