Structure of PolC reveals unique DNA binding and fidelity determinants

PolC is the polymerase responsible for genome duplication in many Gram-positive bacteria and represents an attractive target for antibacterial development. We have determined the 2.4-Å resolution crystal structure of Geobacillus kaustophilus PolC in a ternary complex with DNA and dGTP. The structure...

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Main Authors: Evans, Ronald J., Davies, Douglas R., Bullard, James M., Christensen, Jeffrey, Green, Louis S., Guiles, Joseph W., Pata, Janice D., Ribble, Wendy K., Janjic, Nebojsa, Jarvis, Thale C.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634937/
https://ncbi.nlm.nih.gov/pubmed/19106298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809989106
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