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Oscillations of the p53-Akt Network: Implications on Cell Survival and Death

Intracellular protein levels of p53 and MDM2 have been shown to oscillate in response to ionizing radiation (IR), but the physiological significance of these oscillations remains unclear. The p53-MDM2 negative feedback loop – the putative cause of the oscillations – is embedded in a network involvin...

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Bibliografski detalji
Glavni autori: Wee, Keng Boon, Surana, Uttam, Aguda, Baltazar D.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634840/
https://ncbi.nlm.nih.gov/pubmed/19197384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004407
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