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The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme: A biological perspective
Insulin-degrading enzyme (IDE) is a conserved Zn(2+)metalloendopeptidase involved in insulin degradation and in the maintenance of brain steady-state levels of amyloid β peptide (Aβ) of Alzheimer's disease (AD). Our recent demonstration that IDE and Aβ are capable of forming a stoichiometric an...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2634517/ https://ncbi.nlm.nih.gov/pubmed/19098445 |
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