P-Selectin Cross-Links PSGL-1 and Enhances Neutrophil Adhesion to Fibrinogen and ICAM-1 in a Src Kinase-Dependent, but GPCR-Independent Mechanism

Endothelial and platelet P-selectin (CD62P) and leukocyte integrin α(M)β(2) (CD11bCD18, Mac-1) are cell adhesion molecules essential for host defense and innate immunity. Upon inflammatory challenges, P-selectin binds to PSGL-1 (P-selectin glycoprotein ligand-1, CD162) to mediate neutrophil rolling,...

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Autores principales: Xu, Tao, Zhang, Lei, Geng, Zhen H, Wang, Hai-Bo, Wang, Jin-Tao, Chen, Ming, Geng, Jian-Guo
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2007
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634010/
https://ncbi.nlm.nih.gov/pubmed/19262138
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