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Manganese Superoxide Dismutase Modulates Hypoxia Inducible Factor-1 alpha Induction via Superoxide
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays an important role in O(2) homeostasis. Numerous observations suggest that changes in reactive oxygen species affect HIF-1α stabilization and HIF-1α transcriptional activation in many cell types. The antioxidant enzyme manganese...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2633869/ https://ncbi.nlm.nih.gov/pubmed/18413745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-2635 |
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