Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity

Targeted therapy against epidermal growth factor receptor (EGFR) represents a major therapeutic advance in lung cancer treatment. Somatic mutations of the EGFR gene, most commonly L858R (exon 21) and short in-frame exon 19 deletions, have been found to confer enhanced sensitivity towards the inhibit...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Tang, Zhe, Jiang, Shan, Du, Runlei, Petri, Edward T., El-Telbany, Ahmed, Chan, Perry S.O., Kijima, Takashi, Dietrich, Sascha, Matsui, Kaoru, Kobayashi, Masashi, Sasada, Shinji, Okamoto, Norio, Suzuki, Hideaki, Kawahara, Kunimitsu, Iwasaki, Teruo, Nakagawa, Katsuhiro, Kawase, Ichiro, Christensen, James G., Hirashima, Tomonori, Halmos, Balazs, Salgia, Ravi, Boggon, Titus J., Kern, Jeffrey A., Ma, Patrick C.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2008
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633425/
https://ncbi.nlm.nih.gov/pubmed/19015641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.411
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