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P21/Cip1 and P27/Kip1 are Essential Molecular Targets of Inositol Hexaphosphate for Its Antitumor Efficacy against Prostate Cancer
Inositol hexaphosphate (IP6) causes G1 arrest and increases cyclin-dependent kinase inhibitors (CDKI) p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53. However, whether CDKI induction by IP6 plays any role in its antitumor efficacy is unknown. He...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2633420/ https://ncbi.nlm.nih.gov/pubmed/19176374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3115 |
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