P21/Cip1 and P27/Kip1 are Essential Molecular Targets of Inositol Hexaphosphate for Its Antitumor Efficacy against Prostate Cancer

Inositol hexaphosphate (IP6) causes G1 arrest and increases cyclin-dependent kinase inhibitors (CDKI) p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53. However, whether CDKI induction by IP6 plays any role in its antitumor efficacy is unknown. He...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Roy, Srirupa, Gu, Mallikarjuna, Ramasamy, Kumaraguruparan, Singh, Rana P., Agarwal, Chapla, Siriwardana, Sunitha, Sclafani, Robert A., Agarwal, Rajesh
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633420/
https://ncbi.nlm.nih.gov/pubmed/19176374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3115
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares