P21/Cip1 and P27/Kip1 are Essential Molecular Targets of Inositol Hexaphosphate for Its Antitumor Efficacy against Prostate Cancer

Inositol hexaphosphate (IP6) causes G1 arrest and increases cyclin-dependent kinase inhibitors (CDKI) p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53. However, whether CDKI induction by IP6 plays any role in its antitumor efficacy is unknown. He...

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Bibliographic Details
Main Authors: Roy, Srirupa, Gu, Mallikarjuna, Ramasamy, Kumaraguruparan, Singh, Rana P., Agarwal, Chapla, Siriwardana, Sunitha, Sclafani, Robert A., Agarwal, Rajesh
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633420/
https://ncbi.nlm.nih.gov/pubmed/19176374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3115
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