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Repression of Nascent Strand Elongation by Deregulated Cdt1 during DNA Replication in Xenopus Egg Extracts

Excess Cdt1 reportedly induces rereplication of chromatin in cultured cells and Xenopus egg extracts, suggesting that the regulation of Cdt1 activity by cell cycle-dependent proteolysis and expression of the Cdt1 inhibitor geminin is crucial for the inhibition of chromosomal overreplication between...

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Autors principals: Tsuyama, Takashi, Watanabe, Saori, Aoki, Ayako, Cho, Yunje, Seki, Masayuki, Enomoto, Takemi, Tada, Shusuke
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633378/
https://ncbi.nlm.nih.gov/pubmed/19064889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-06-0613
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