TLR6 drives differentiation of tolerogenic DC and contributes to LcrV-mediated plague pathogenesis

Innate signals underlying the differentiation of tolerogenic dendritic cells (DC) remain ill defined. Here we show that TLR6 associated with TLR2 uniquely induces IL-10 producing DC and type-1 regulatory T cells. In contrast TLR1 associated with TLR2 promotes differentiation of IL-12p40 producing DC...

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Detalhes bibliográficos
Main Authors: DePaolo, R. William, Tang, Fangming, Kim, In Young, Han, Mei, Levin, Nadine, Ciletti, Nancy, Lin, Anning, Anderson, Debra, Schneewind, Olaf, Jabri, Bana
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633104/
https://ncbi.nlm.nih.gov/pubmed/18854239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.09.004
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