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Fluorine substituted adenosines as probes of nucleobase protonation in functional RNAs
Ionized nucleobases are required for folding, conformational switching or catalysis in a number of functional RNAs. A common strategy to study these sites employs nucleoside analogs with perturbed pK(a), but the interpretation of these studies is often complicated by the chemical modification introd...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2633102/ https://ncbi.nlm.nih.gov/pubmed/18803382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja803336y |
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