Nortriptyline Protects Mitochondria and Reduces Cerebral Ischemia/Hypoxia Injury

BACKGROUND AND PURPOSE: Nortriptyline, an antidepressant, was identified as a strong inhibitor of mitochondrial permeability transition by our screening of a library of 1040 drugs. Because mitochondrial permeability transition and consequent mitochondrial dysfunction have been implicated in acute ne...

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Bibliografiske detaljer
Main Authors: Zhang, Wen-hua, Wang, Hongyan, Wang, Xin, Narayanan, Malini V., Stavrovskaya, Irina G., Kristal, Bruce S., Friedlander, Robert M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632945/
https://ncbi.nlm.nih.gov/pubmed/18174477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.107.496810
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