Deletion of the Mitochondrial Flavoprotein Apoptosis Inducing Factor (AIF) Induces β-Cell Apoptosis and Impairs β-Cell Mass

BACKGROUND: Apoptosis is a hallmark of β-cell death in both type 1 and type 2 diabetes mellitus. Understanding how apoptosis contributes to β-cell turnover may lead to strategies to prevent progression of diabetes. A key mediator of apoptosis, mitochondrial function, and cell survival is apoptosis i...

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Detalhes bibliográficos
Main Authors: Schulthess, Fabienne T., Katz, Sophie, Ardestani, Amin, Kawahira, Hiroshi, Georgia, Senta, Bosco, Domenico, Bhushan, Anil, Maedler, Kathrin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632884/
https://ncbi.nlm.nih.gov/pubmed/19197367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004394
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