Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis

BACKGROUND: Single genome-wide screens for the effect of altered gene dosage on drug sensitivity in the model organism Saccharomyces cerevisiae provide only a partial picture of the mechanism of action of a drug. RESULTS: Using the example of the tumor cell invasion inhibitor dihydromotuporamine C,...

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Main Authors: Kemmer, Danielle, McHardy, Lianne M, Hoon, Shawn, Rebérioux, Delphine, Giaever, Guri, Nislow, Corey, Roskelley, Calvin D, Roberge, Michel
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2009
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Research article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632640/
https://ncbi.nlm.nih.gov/pubmed/19144191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-9-9
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