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Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis
BACKGROUND: Single genome-wide screens for the effect of altered gene dosage on drug sensitivity in the model organism Saccharomyces cerevisiae provide only a partial picture of the mechanism of action of a drug. RESULTS: Using the example of the tumor cell invasion inhibitor dihydromotuporamine C,...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2632640/ https://ncbi.nlm.nih.gov/pubmed/19144191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-9-9 |
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