Long-Term Reversal of Cholinergic Neuronal Decline in Aged Non-Human Primates by Lentiviral NGF Gene Delivery

Spontaneous atrophy of basal forebrain cholinergic neurons occurs with aging in the non-human primate brain. Short-term reversal of this atrophy has been reported following ex vivo Nerve Growth Factor (NGF) gene delivery, but long-term effects of in vivo NGF gene delivery in the aged primate brain h...

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Main Authors: Nagahara, Alan H., Bernot, Tim, Moseanko, Rod, Blesch, Armin, Conner, James M., Ramirez, Anthony, Gasmi, Mehdi, Tuszynski, Mark H.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632603/
https://ncbi.nlm.nih.gov/pubmed/19013154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2008.10.004
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