JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration

Activation of c-jun N-terminal kinase (JNK) by the mitogen-activated protein kinase cascade has been shown to play an important role in the death of dopamine neurons of the substantia nigra, one of the principal neuronal populations affected in Parkinson’s disease. However, it has remained unknown w...

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Hlavní autoři: Ries, Vincent, Silva, Robert M., Oo, Tinmarla F., Cheng, Hsiao-Chun, Rzhetskaya, Margarita, Kholodilov, Nikolai, Flavell, Richard A., Kuan, Chia-Yi, Rakic, Pasko, Burke, Robert E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632584/
https://ncbi.nlm.nih.gov/pubmed/19014392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05713.x
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