JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration

Activation of c-jun N-terminal kinase (JNK) by the mitogen-activated protein kinase cascade has been shown to play an important role in the death of dopamine neurons of the substantia nigra, one of the principal neuronal populations affected in Parkinson’s disease. However, it has remained unknown w...

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Main Authors: Ries, Vincent, Silva, Robert M., Oo, Tinmarla F., Cheng, Hsiao-Chun, Rzhetskaya, Margarita, Kholodilov, Nikolai, Flavell, Richard A., Kuan, Chia-Yi, Rakic, Pasko, Burke, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632584/
https://ncbi.nlm.nih.gov/pubmed/19014392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05713.x
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