PDE5 Inhibitors Enhance Tumor Permeability and Efficacy of Chemotherapy in a Rat Brain Tumor Model

The blood-brain tumor barrier (BTB) significantly limits delivery of therapeutic concentrations of chemotherapy to brain tumors. A novel approach to selectively increase drug delivery is pharmacologic modulation of signaling molecules that regulate BTB permeability, such as those in cGMP signaling....

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Detalhes bibliográficos
Main Authors: Black, Keith L., Yin, Dali, Ong, John M., Hu, Jinwei, Konda, Bindu M., Wang, Xiao, Ko, MinHee K., Bayan, Jennifer-Ann, Sacapano, Manuel R., Espinoza, Andreas, Morris-Irvin, Dwain K, Shu, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632551/
https://ncbi.nlm.nih.gov/pubmed/18674521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2008.06.122
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