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Effect of cysteine mutagenesis on the function and disulfide bond formation of human ABCG2

ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily. Its over-expression causes multidrug resistance in cancer chemotherapy. Based on its apparent half size in sequence when compared to other traditional ABC transporters, ABCG2 has been thought to exist and function as a homo...

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Autors principals: Liu, Yang, Yang, Youyun, Qi, Jing, Peng, Hui, Zhang, Jian-Ting
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632310/
https://ncbi.nlm.nih.gov/pubmed/18430864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.138115
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