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SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs
UPF1 functions in both Staufen 1 (STAU1)-mediated mRNA decay (SMD) and nonsense-mediated mRNA decay (NMD), which we show here are competitive pathways. STAU1- and UPF2-binding sites within UPF1 overlap so that STAU1 and UPF2 binding to UPF1 appear to be mutually exclusive. Furthermore, down-regulati...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2632170/ https://ncbi.nlm.nih.gov/pubmed/19095803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1717309 |
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