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Membrane Hyperpolarization Drives Cation Influx and Fungicidal Activity of Amiodarone
Cationic amphipathic drugs, such as amiodarone, interact preferentially with lipid membranes to exert their biological effect. In the yeast Saccharomyces cerevisiae, toxic levels of amiodarone trigger a rapid influx of Ca(2+) that can overwhelm cellular homeostasis and lead to cell death. To better...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2631971/ https://ncbi.nlm.nih.gov/pubmed/19054772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806693200 |
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