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Synthesis and CB1 Cannabinoid Receptor Affinity of 4-Alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles
A series of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles were synthesized regioselectively using click chemistry and evaluated at CB1 cannabinoid receptors. The n-propyl ester 11 (K(i) = 4.6 nM) and phenyl ester 14 K(i) = 11 nM) exhibited the most potent affinity of the series.
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2631625/ https://ncbi.nlm.nih.gov/pubmed/19097888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.11.110 |
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