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Synthesis and Monoamine Transporter Affinity of 3α-Arylmethoxy-3β-arylnortropanes

A series of 3-arylnortrop-2-enes and 3α-arylmethoxy-3β-arylnortropanes were synthesized and evaluated for binding affinity at monoamine transporters. The 3-(3,4-dichlorophenyl)nortrop-2-ene (6e) exhibited high affinity for the SERT (K(i) = 0.3 nM). The 3α-arylmethoxy-3β-arylnortropanes were generall...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Kaur, Harneet, Izenwasser, Sari, Verma, Abha, Wade, Dean, Housman, Amy, Stevens, Edwin D., Mobley, David L., Trudell, Mark L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788963/
https://ncbi.nlm.nih.gov/pubmed/19896846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.087
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