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A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer
The MDM2 oncoprotein is a key negative regulator of the tumor suppressor p53. A functional MDM2 single nucleotide polymorphism (SNP309) in the promoter region increases the affinity of transcription activator Sp1 for the MDM2 gene promoter, resulting in higher expression of MDM2 and thus inhibition...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2631619/ https://ncbi.nlm.nih.gov/pubmed/18814047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10552-008-9231-9 |
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