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P21(Cip1) Protects against Oxidative Stress by Suppressing ER Dependent Activation of Mitochondrial Death Pathways

Although it is well established that the cell cycle inhibitor p21 protects against genotoxic stress by preventing the replication of damaged DNA, recent studies have shown cytoplasmic forms can also protect. It protects by delaying the loss of the anti-apoptotic proteins, Mcl-1 and Bcl-X(L); however...

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Detalhes bibliográficos
Main Authors: Vitiello, Peter F., Wu, Yu-Chieh M., Staversky, Rhonda J., O’Reilly, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631574/
https://ncbi.nlm.nih.gov/pubmed/18948188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2008.09.022
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