Valproate Attenuates Accelerated Atherosclerosis in Hyperglycemic ApoE-Deficient Mice : Evidence in Support of a Role for Endoplasmic Reticulum Stress and Glycogen Synthase Kinase-3 in Lesion Development and Hepatic Steatosis

We have previously shown that glucosamine promotes endoplasmic reticulum (ER) stress in vascular cells leading to both inflammation and lipid accumulation—the hallmark features of atherosclerosis. Pretreatment with glycogen synthase kinase (GSK)-3 inhibitors protects cultured cells from ER stress-in...

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Autors principals: Bowes, Anna J., Khan, Mohammad I., Shi, Yuanyuan, Robertson, Lindsie, Werstuck, Geoff H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2009
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631345/
https://ncbi.nlm.nih.gov/pubmed/19095952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080385
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